The derivatives of pyrimidine, oxadiazole and indole in combination compounds were synthesized by Conventional method and Micro wave method .The antimicrobial activity of the synthesized compounds were evaluated on S.aureus , B.subtilis, E.coli and P.aeroginosa. The anti oxidant activity was determined by DPPH assay method. The present investigation deals with the synthesized compounds possessing good antioxidant and antibacterial activity.