Validation of developed and RP HPLC analytical method according to ICH Guidelines. A review of
literature reveals that no analytical methods are available for these drugs. There are no methods in the
literature for the estimation of drugs in combined dosage forms. Analytical methods have been report for
hydrochlorothiazide and eprosartan using RP-HPLC in pharmaceutical dosage form. The development of
simple and precise reverse phase high performance liquid chromatography of hydrochlorothizide and
eprosartan using single method in bulk in bulk drug and market formulation.