Antidiabetic potential of Withania coagulans Dunal Flower in Streptozotacin Induced Diabetic Rats

M.D. Kitukale

Abstract


The present study was designed to evaluate the anti-diabetic potential of flower of Withania coagulans
Dunal. The dried flowers were extracted successively by methanol and water. These extract then
subjected for phytochemical screening. Animals were divided in seven groups and treated with high dose
(400 mg/kg) and low dose (200 mg/kg) of methanolic and aqueous extract and compared with diabetic
control group. Results of diabetic study indicates that administration of methanolic and aqueous extract of
Withania coagulans Dunal daily for 28 days showed significant decrease in the blood glucose of the STZ
induced diabetic rats compared to the diabetic control rats. The findings of this research suggest that the
methanolic and aqueous extract of Withania coagulans Dunal flower may contains bioactive constituents
with anti-diabetic potential which can be used for the treatment of diabetes mellitus.

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