The leaves of Salvadora persica L. were extracted with petroleum ether, chloroform, and ethyl acetate, ethanol, and water solvents. The ethyl acetate extract was screened for analgesic and anti-inflammatory activities. The analgesic activity was carried out by tail immersion method and anti-inflammatory activity was evaluated by carrageen induced paw edema method. Pretreatment with ethyl acetate extract (500 mg / kg, body weight) showed significant analgesic activity (p< 0.01) comparable to the standard drug pentazocine and against carrageen induced paw edema suppressant activity comparable to the standard drug indomethacin.