Two simple spectrophotometric methods were developed and validated for the determination of ranolazine hydrochloride in the presence of its base-induced degradation product, namely simultaneous equation method using two wavelengths of 272 and 249 nm method (A) and area under the curve method using two wavelength ranges of 267–277 nm and 244–254 nm method (B). The accuracy, precision, and linearity ranges of the planned methods were firm. The methods were validated and the specificity was assessed by analyzing synthetic mixtures containing the drug and it’s degradant. The two methods were useful for the determination of the cited drug in its pharmaceutical preparation and the obtained results were statistically compared with those of a reported method. The comparison shows that there is no important difference between the proposed methods and the reported method about both accuracy and precision.