Nanotechnology in Blood Brain Barrier: A Review

Abstract

Delivery of drugs to brain is still a major challenge. Successful delivery across the blood brain barrier has only been achieved in some cases, for example pro-drugs; alternative approach is delivery to the brain by using nanoparticles. Nanotechnology is expected to bring revolutionary changes in the field of life sciences including drug delivery, diagnostics, neutraceuticals and production of biomaterials. Liposomes can also be used for delivery of drug to the brain through the blood brain barrier (BBB). The review focuses on blood brain barrier, nanoparticles and their preparation, and mechanism of nanoparticles mediated drug transfer across blood brain barrier, application of nanoparticles as biomarkers, and liposomes and their manufacturing.