Evidence-Based Multimodal Management of Severe Post-Asphyxial Cerebral Palsy in a Turkish Girl from Sweden

Abstract

Severe perinatal asphyxia is a major cause of cerebral palsy and neurodevelopmental disability. We report the case of a 22-month-old girl who developed cerebral palsy and developmental delay following hypoxic-ischemic encephalopathy at birth. The patient initially underwent unregulated stem cell therapy abroad without benefit. Based on published evidence and our prior clinical experience with neuroprotective agents, she was treated sequentially with Cerebrolysin, Citicoline, Piracetam, collagen hydrolysate,and nutritional support. Improvements were observed in motor strength, vocalization, and cognitive responsiveness across successive treatment courses. This case highlights the importance of evidence- based medicine in guiding rational therapeutic interventions in complex neurological disorders and in resisting unproven alternative approaches.