Synthesis of 10-[7,11-(2,4 di substituted phenyl)-3-oxo-9-aminoimino-2,4-diazaspiro [5,5] phenothiazine derivatives as anticonvulsant Activity

Abstract

10-chloroacetyl-2-trifluoro methyl phenothiazine (1). 10-[7,11-(2,4 di substituted phenyl)-3-oxo-9-aminoimino-2,4-diazarpiro [5,5] undecane 1,5-dione] acetyl-2-tri fluoro methyl phenothiazines (2-27) were prepared in present study. The newly synthesized compounds were screened for their anticonvulsant activity against electrically (MES) and chemically (PTZ, picrotoxin and bicuculline) induced seizures and compared with the standard drugs phenytoin sodium, Lamotrigine and Sodium valproate. The compound 13 was found to be most potent compound of this series.