Synthesis of 10-[7,11-(2,4 di substituted phenyl)-3-oxo-9-aminoimino-2,4-diazaspiro [5,5] phenothiazine derivatives as anticonvulsant Activity

Authors

  • Anil Kumar *Department of Pharmacology L.LR.M, Medical college Meerut

Abstract

10-chloroacetyl-2-trifluoro methyl phenothiazine (1). 10-[7,11-(2,4 di substituted phenyl)-3-oxo-9-aminoimino-2,4-diazarpiro [5,5] undecane 1,5-dione] acetyl-2-tri fluoro methyl phenothiazines (2-27) were prepared in present study. The newly synthesized compounds were screened for their anticonvulsant activity against electrically (MES) and chemically (PTZ, picrotoxin and bicuculline) induced seizures and compared with the standard drugs phenytoin sodium, Lamotrigine and Sodium valproate. The compound 13 was found to be most potent compound of this series.

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How to Cite

Kumar, A. (2011). Synthesis of 10-[7,11-(2,4 di substituted phenyl)-3-oxo-9-aminoimino-2,4-diazaspiro [5,5] phenothiazine derivatives as anticonvulsant Activity. International Journal of Pharmaceutical & Biological Archive, 2(1). Retrieved from http://ijpba.info/index.php/ijpba/article/view/193

Issue

Vol. 2 No. 1 (2011): International Journal of Pharmaceutical and Biological Archive

Section

Research Articles

License

This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.