Evaluation of Hepatoprotective Activity of Flowers of “Tagetes erecta linn”

Abstract

ABSTRACT In the present study, the hepatoprotective activity of the ethanolic extract of flowers of Tagetes erecta was carried out. For the study, male wister rats weighing 200-250gm were used and divided into six group of four in each. Experimentally induced hepatotoxicity by using CCl4 /olive oil (1:1, 3ml/kg, i.p.for seven days), silymarin suspended in 0.6% c.m.c.( 100mg/kg, orally. For seven days) as standard reference and 100mg, 200mg, and 400mg/kg of ethanolic extract of flowers of plant Tagetes erecta for seven consecutive days orally followed by CCl4 injection on day seven. Pre-treatment with ethanolic extract of Tagetes erecta reduced the biochemical markers of hepatic injury like SGPT, SGOT, ALP and bilirubin levels and histopathological examination showned 200 and 400mg/kg showed hepatoprotective property. This results indicate the flower of tagetes erecta possess hepatoprotective property may be attributed to the quercetin related flavonoids present in the flower of Tagetes erecta.