Hepatoprotective Activity Of Sesamum Indicum Linn. Against Ccl4-Induced Hepatic Damage In Rats

Authors

  • Munish Kumar

Abstract

ABSTRACT In present study, the hepatoprotective activity of ethanolic extracts of Sesamum indicum Linn. seeds were evaluated against carbon tetrachloride (CCL4) induced hepatic damage in rats. The extract at two different doses (400mg/kg and 700mg/kg) was administered orally once daily. The substantially elevated serum enzymatic level of Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyurvate Transaminase (SGPT), alkaline phosphatase (ALP), Acid phosphatase (ACP), Total Protein, Albumin and Total Bilirubin were restored towards normalization significantly by the extract. The biochemical observations were supplemented with histopathological examination of rat liver sections. The results of this study strongly indicate the Sesamum indicum Linn. Seeds have potent hepatoprotective action against carbon tetrachloride induced hepatic damage in rats.

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How to Cite

Kumar, M. (2011). Hepatoprotective Activity Of Sesamum Indicum Linn. Against Ccl4-Induced Hepatic Damage In Rats. International Journal of Pharmaceutical & Biological Archive, 2(2). Retrieved from http://ijpba.info/index.php/ijpba/article/view/233

Issue

Vol. 2 No. 2 (2011): IJPBA

Section

Research Articles

License

This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.