Protective and Curative Effects Of Justicia tranquebariensis (Linn) Leaves In Acetamenophen Induced Hepatotoxicity

Authors

  • Shabana Begum M 1Department of Biochemistry, MCAS, Rasipuram, Namakkal, Tamilnadu, India.

Abstract

ABSTRACT The purpose of this study was to evaluate the protective and curative effect of Justicia tranquebariensis leaf extract (JTLE) using acetaminophen - induced liver injury in mice. The leaf extract at dosage of 500 and 1000 mg/kg exhibited significant protective effect against acetaminophen induced hepatotoxicity. Level of serum markers such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and total bilirubin (TB) were significantly increased in acetaminophen treated mice. Simultaneously, Justicia tranquebariensis leaf extract significantly suppressed mainly the increase in plasma activities of AST, ALT, ALP and TB concentration, which are considered as markers of liver functional state. The results of this study confirmed the protective and curative effect of the aqueous leaf extract of Justicia tranquebariensis.

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How to Cite

M, S. B. (2011). Protective and Curative Effects Of Justicia tranquebariensis (Linn) Leaves In Acetamenophen Induced Hepatotoxicity. International Journal of Pharmaceutical & Biological Archive, 2(3). Retrieved from http://ijpba.info/index.php/ijpba/article/view/304

Issue

Vol. 2 No. 3 (2011): International Journal of Pharmaceutical and Biological Archieve

Section

Research Articles

License

This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.