Simultaneous UV-Spectrophotometric Estimation of Glipizide and Metformin in Bulk and Its Dosage Form

Authors

  • Rashmi Ranjan Sarangi Department of Pharmaceutical Analysis and Quality Assurance,Royal College of Pharmacy and Health Sciences, Andhapasara Road, Berhampur-760002, Odisha, India

Abstract

ABSTRACT: A simple, accurate, validated and reproducible UV-Spectrophotometric method has been developed for the simultaneous estimation of Glipizide Hydrochloride and Metformin in both bulk and tablet formulation. Glipizide and Metformin in combined tablet formulation were estimated by using the multi component mode at 276 nm for Glipizide and 237 nm for Metformin in their solution in methanol. The Beer’s law obeyed the concentration range of 2-20µg/ml for both Glipizide and Metformin. Mean recovery of 99.90% for Glipizide and 99.99% for Metformin respectively signifies the accuracy of the method. This method can be used for the routine simultaneous estimation of Glipizide and Metformin in industries and other analytical laboratories.

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How to Cite

Sarangi, R. R. (2011). Simultaneous UV-Spectrophotometric Estimation of Glipizide and Metformin in Bulk and Its Dosage Form. International Journal of Pharmaceutical & Biological Archive, 2(4). Retrieved from http://ijpba.info/index.php/ijpba/article/view/347

Issue

Vol. 2 No. 4 (2011): IJPBA

Section

Research Articles

License

This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.