A Validated UV-Spectrophotometric Method for the Estimation of Tinidazole in Bulk and Pharmaceutical Dosage Form

Authors

  • Umadevi Kothapalli Department of Pharmaceutical Analysis and Quality Assurance, Royal College of Pharmacy and Health Sciences, Andhapasara Road, Berhampur, Odisha, India.

Abstract

ABSTRACT: A new, simple, precise and accurate method for the estimation of Tinidazole in bulk and pharmaceutical dosage forms has been developed. 0.1N HCl was chosen as the solvent system. The λmax was found to be 278nm. The responses were linear in the range of 10-80µg/ml. The regression equation of the calibration graph and correlation coefficient were found to be y = 0.026x - 0.042 and 0.999 respectively. Validation of the method was done in order to demonstrate accuracy, precision, interday and intraday assay, robustness and ruggedness of the proposed method. The %RSD values for both intraday and interday precision were less than 1%. The recovery of the drug from the sample was ranged between 99.12% and 100.96%. Commercial tablets containing 500mg and 300mg of Tinidazole (COZIT and TINA respectively) were analyzed by the proposed method and the results were well within the claimed limits.

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How to Cite

Kothapalli, U. (2011). A Validated UV-Spectrophotometric Method for the Estimation of Tinidazole in Bulk and Pharmaceutical Dosage Form. International Journal of Pharmaceutical & Biological Archive, 2(4). Retrieved from http://ijpba.info/index.php/ijpba/article/view/349

Issue

Vol. 2 No. 4 (2011): IJPBA

Section

Research Articles

License

This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.