Formulation and Evaluation of Mouth Dissolving Tablets of Chlorpromazine Hcl

Abstract

ABSTRACT Chlorpromazine HCl is a potent anti-emetic, act by blocking D2 receptors in the Chemoreceptor trigger zone (CTZ), and antagonize apomorphine induced vomiting. In the present study an attempt has been made to prepare fast dissolving tablets of Chlorpromazine HCl in the oral cavity with enhanced dissolution rate. The tablets were prepared with five superdisintegrants eg: Sodium starch glycolate , Crospovidone ,Croscarmellose, L-HPC, Pregelatinised starch , The blend was examined for angle of repose, bulk density, tapped density , compressibility index and hausners ratio. The tablets were evaluated for hardness, friability, disintegration time, dissolution rate, drug content, and were found to be within 1 min. It was concluded that the fast dissolving tablets with proper hardness, rapidly disintegrating with enhanced dissolution can be made using selected superdisintegrants.